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Promethazine is prescribed for the treatment of allergic disorders, itching, nausea and vomiting.
Promethazine is prescribed to relieve the symptoms of allergic reactions such as allergic rhinitis (runny nose and watery eyes caused by allergy to pollen, mold or dust), allergic conjunctivitis (red, watery eyes caused by allergies), allergic skin reactions, and allergic reactions to blood or plasma products. Promethazine is prescribed with other prescriptions to treat anaphylaxis (sudden, severe allergic reactions) and the symptoms of the common cold such as sneezing, cough, and runny nose. Promethazine is also used to relax and sedate patients before and after surgery, during labor, and at other times. Promethazine is also used to prevent and control nausea and vomiting that may occur after surgery, and with other prescriptions to help relieve pain after surgery. Promethazine is also used to prevent and treat motion sickness. Promethazine helps control symptoms, but will not treat the cause of the symptoms or speed recovery. Promethazine is in a class of prescriptions called phenothiazines. It works by blocking the action of a certain natural substance in the body.
A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is prescribed as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.
Injection: Promethazine is contraindicated in comatose states, in patients who have received large amounts of central-nervous-system depressants (alcohol, sedative hypnotics, including barbiturates, general anesthetics, narcotics, narcotic analgesics, tranquilizers, etc.), and in patients who have demonstrated an idiosyncrasy or hypersensitivity to promethazine.
Under no circumstances should promethazine be given by intra-arterial injection due to the likelihood of severe arteriospasm and the possibility of resultant gangrene
Promethazine HCl injection should not be given by the subcutaneous route; evidence of chemical irritation has been noted, and necrotic lesions have resulted on rare occasions following subcutaneous injection. The preferred parenteral route of administration is by deep intramuscular injection.
Syrup, Tablets and Suppositories: Promethazine Tablets and Suppositories are contraindicated for use in pediatric patients less than two years of age.
Promethazine Tablets and Suppositories are contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines.
Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms including asthma.
Without a Prescription
Promethazine comes as a tablet and syrup (liquid) to take by mouth and as a suppository to use rectally. When promethazine is used to treat allergies, it is usually taken one to four times daily, before meals and/or at bedtime. When promethazine is used to relieve cold symptoms, it is usually taken every 4-6 hours as needed. When promethazine is used to treat motion sickness, it is taken 30-60 minutes before travel and again after 8-12 hours if needed. On longer trips, promethazine is usually taken in the morning and before the evening meal on each day of travel. When promethazine is used to treat or prevent nausea and vomiting it is usually taken every 4-6 hours as needed. Promethazine may also be taken at bedtime the night before surgery to relieve anxiety and produce quiet sleep.
Promethazine suppositories are for rectal use only. Do not try to swallow the suppositories or insert in any other part of your body.
If you are taking promethazine liquid, do not use a household spoon to measure your dose. Use the measuring spoon or cup that came with the prescription or use a spoon made especially for measuring prescription.
To insert a promethazine suppository, follow these steps:
* If the suppository feels soft, hold it under cold, running water for 1 minute. Remove the wrapper.
* Dip the tip of the suppository in water.
* Lie down on your left side and raise your right knee to your chest. (A left-handed person should lie on the right side and raise the left knee.)
* Using your finger, insert the suppository into the rectum, about ? to 1 inch in children who are 2 years of age older and 1 inch in adults. Hold it in place for a few moments.
* Stand up after about 15 minutes. Wash your hands thoroughly and resume your normal activities.
Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Promethazine side effects that you should report to your health care professional or doctor as soon as possible:
- abnormal excitement or agitation;
- abnormal neck position;
- abnormal or uncontrollable movements;
- abnormally happy mood;
- blurred or double vision;
- breathing stops for a short time;
- continuous twisting movements of the hands and feet;
- decreased alertness;
- difficulty breathing;
- difficulty breathing or swallowing;
- difficulty falling asleep or staying asleep;
- dry mouth;
- fast heartbeat;
- fast or irregular pulse or heartbeat;
- hallucinations (seeing things or hearing voices that do not exist);
- inability to respond to people around you;
- loss of consciousness;
- loss of coordination;
- overwhelming or unmanageable fear or emotion;
- ringing in ears;
- slowed breathing;
- slowed or stopped breathing;
- sore throat, fever, chills, and other signs of infection;
- stiff muscles;
- stuffy nose;
- swelling of the face, eyes, lips, tongue, throat, arms, hands, feet, ankles, or lower legs;
- tight muscles that are difficult to move;
- tongue sticking out;
- uncontrollable shaking of a part of the body;
- uncontrolled eye movements;
- unusual bruising or bleeding;
- upset stomach;
- wide pupils (black circles in the middle of the eyes);
- yellowing of the skin or eyes;